Ovarian Stimulation Procedure for IVF

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Ovarian Stimulation Procedure for IVF

In successful assisted reproduction, the procedure of ovarian stimulation for IVF plays a significant role.

This is the stage where doctors advise hormonal drugs that stimulate the ovaries of a woman to produce 5 to 10 mature eggs, or oocytes, instead of a single egg at normal ovulation.

These eggs will then be removed from the ovaries and fertilized with sperm in the laboratory.

The advantage of having multiple sites in one menstrual cycle is that it

  • Enhances chances of having more than one viable egg for fertilization. 
  • Helps to create many embryos that increase the chances of conception.
  • May provide additional embryos for use in future pregnancies.

Medicines or fertility drugs are given under the supervision of an IVF specialist. They can be either oral or injections.

Working of Ovarian Stimulation

First, patients have a complete infertility assessment at an EVA IVF hospital.

This includes factors such as age, anterior follicle count, ovarian reserve hormone testing, pre-treatment, and final infertility screening.

Once it is confirmed that the patient will go for in-vitro-fertilization, the process of ovarian stimulation for IVF is started.

There are a number of options for this, including a series of different medications administered over several days or weeks.

This is the protocol of stimulation. However, there is no one method that works for every woman undergoing the treatment of fertility.

Some patients may produce too few eggs, while others may be overstimulated.

For some, the stimulation period may be shorter than for others whose follicles mature faster.

Fertilization Success Choosing the proper ovarian stimulation is critical to your chances of IVF success. This can greatly affect the quality of eggs.

Dr. Shivani Bhutani recommends the suitable dosage as well as the time of starting the medicine to each patient. 

The quality of the egg can have detrimental effects by having excess or less medicine.

The procedure begins with pressure on the ovaries using birth control pills. When ovulation is achieved, the recombinant follicle-stimulating hormone is given to stimulate the ovaries.

The ovaries and fallopian tubes are then closely monitored by ultrasound every three to four days with blood hormone testing.

After many follicles (pockets containing ova) become large enough, ovulation begins with HCG.

The eggs are retrieved on the third day. 

The drugs used for stimulation are derivatives of two hormones, follicle-stimulating hormone and luteinizing hormone (LH). These are known as gonadotropins.

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What are Gonadotropins?

It is a combination of those two hormones which are used in IVF under the procedure of ovarian stimulation.

These are named luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and both are secreted by the Pituitary gland. They stimulate the ovaries naturally to

  • Produce a follicle that contains an ovary (oocyte)
  • Release egg from the ovary

Most gonadotropin preparations used to treat infertility are formulated in a laboratory (called recombinant preparations) and must be injected subcutaneously to be effective.

For most females, only FSH injection treatment is recommended. For those who do not have regular periods, a combination of both LH and FSH is usually required.

FSH stimulates the follicles to grow better during the menstrual cycle. Generally, many follicles die before ovulation because the level of FSH in the blood drops.

However, when high levels of FSH are maintained with injections, it stimulates the ovaries to produce more mature eggs.

Before ovulation, progesterone causes a spike in LH, which causes ovulation.

Administration of a large dose of human chorionic gonadotropin (hCG) stimulates ovulation, which initiates the process.

How to prepare yourself for Ovarian Stimulation

When a couple is being treated and evaluated at the Eva Fertility Center,

They should pay proper attention to their medicine calendar and follow directions carefully to have the best chance of successful egg retrieval.

You can also pay attention to diet and stress levels because they also affect hormone levels.


  1. Eat a healthy and balanced diet.
  2. Start taking vitamins. 
  3. Maintain a healthy weight.
  4. Quit smoking, alcohol, and recreational drug use.
  5. Reduce caffeine intake.

Management of Stress

Practice light yoga, meditation, and a good amount of communication between husband and wife to manage stress.

You can become a part of a support group or take counseling as suggested by your IVF specialist at Eva.

Many couples are overwhelmed by the fears and anxieties that come with ART treatment.

There is nothing to worry about though. Instead of panicking, you should learn about the whole process.

You can refer to our other blog posts that explain every aspect of the process and the availability of huge possibilities for you as a couple.

About The Author

Dr Shivani Bhutani
A doctor with a rich background and high success rate, Dr. Shivani Bhutani offers the boon of parenthood to couples dealing with infertility. She has opulent knowledge and expertise in offering successful treatment for infertility in females, gynecological disorders, and family planning consultation services. Highly dedicated, concerned, and attentive, Dr. Shivani understands the bliss of parenthood and offers appropriate medical help.